Our wart vaccine has been approved for vaccination of cattle 60 days of age or older against bovine papillomavirus.
During the vaccine development process, Cambridge conducted three separate field safety studies at various locations around the country, enrolling more than 900 cattle of various age, breed, and gender. The studies required a series of three vaccinations of 4mL experimental serial, followed by observation and palpation of vaccination sites.
Immediately and up to 24 hours post-injection observation times, palpable injection site reactions (ISR) were recorded in 19 of the 204 vaccinated animals in Iowa and 155 of the 241 vaccinates in Illinois. All but one of the palpable injection site reactions at these sites had returned to normal by 14 days post-primary injection. Two weeks after the final injection, three animals in IL had a palpable reaction, but all three animals were normal on day 56. In IA, two animals developed a chronic reaction that had not resolved by day 70.
In California, where minimum age cattle (60-61 days of age) were enrolled, a larger number of the vaccinated calves had palpable ISR following each of the three injections. However, these animals also received whole-herd vaccinations during the study. The cooperating veterinarian for that site did not view the ISR incidence and the overall herd health status during the study term as outside what he considered routine and ordinary for this production unit.
Click Here or a complete report of the three field safety studies conducted on this product.