Cambridge Technologies uses Precision Vaccinology®, a combination of Next Generation Diagnostics and Quality Custom Manufacturing, to help veterinarians find solutions to herd health problems.
It starts in our full-service diagnostics laboratory, featuring next-generation sequencing, new techniques to identify all known and unknown viruses, and bacteria in samples from a herd. We use the data to select the best candidates for a herd-specific vaccine which we custom manufacture for the veterinarian with formulations optimized to meet your specific needs. Our goal is to identify emerging pathogens, prevent disease they may cause, and reduce dependence on antibiotics.
(for unknown pathogens)
The Metagenome is essentially all the genetic material that is present in a sample. Metagenomics, an advanced technology, is the process of sequencing this genetic material and identifying all the bacteria and viruses in a sample. We then search for those that may be associated with the disease syndrome, from there we can make further efforts to grow the bacteria or viruses for a custom vaccine.
(for known pathogens)
Multilocus sequence typing or MLST allows us to very precisely compare the genetic diversity of multiple isolates from your farm or other farms in your area. It allows us to keep track of how pathogens are evolving and aids us in selecting the right isolates for an up-to-date vaccine.
Vaccine Formulation and Development
One key component of Precision Vaccinology® is the expression of virulence and pathogenic factors during the manufacturing process. Toxins, proteins, etc., that have been identified as being part of the selected isolate, would potentially be ideal to include in an inactivated vaccine in an attempt to selectively target the pathogen. By developing an immune response to key virulence factors via vaccination, the pathogen can be rendered innocuous.
Precision Vaccinology® also considers the adjuvant and route of administration to generate the best immune outcome. Certain adjuvants can enhance the immune response and/or aid in the administration of the antigen. There are multiple options to choose from when deciding on a route of administration and often they can be chosen based on the preference of the particular farm that the product is being manufactured for. Custom vaccines can be developed for intranasal, intramuscular, intraperitoneal, or subcutaneous administration.